Drawing on fieldwork in California, I look at the ways in which regenerative, reproductive and genomic sciences are enabling new forms of governance and subjectivity.  I follow an emerging biopolitical logic that I call « pro-activism, » that simultaneously mobilises neoliberal and statist biopolitical paradigms, linked through disease advocacy, the rise of the forensic and biometric state, and a so-called bench-to-bedside translational innovation mandate that incorporates the public, research entities, the state, and private capital in new configurations. What is life? Who is a parent?  What is a family?  Which notions of peoplehood are salient in this biopolitical logic?  Who owns one’s biomaterial and bio-information? In what ways is pro-activism redistributive and a form of resistance and change, and in what ways does it recycle or create new forms of stratification?